Announcing SimHumanity, a baseline SLiM 5.0 model of the full human genome, replete with demographic history, autosomes, X/Y, and mtDNA. A shared starting point for reproducible evolutionary simulations. We’d love your feedback! #SLiM #evolution #genomics https://www.biorxiv.org/content/10.1101/2025.09.01.673541v1

Scientists discover molecular brake that limits T cell attack on tumors

In a discovery that could expand the array of current cancer immunotherapy treatments, scientists at Harvard Medical School…
#NewsBeep #News #Health #AU #Australia #Cancer #CancerImmunotherapy #Cell #CRISPR #Cytokine #Cytokines #Gene #Genomics #GlaxoSmithKline #ImmuneSystem #Immunology #Immunotherapy #MedicalSchool #Molecule #protein #research #T-Cell #Therapeutics #Tumor
https://www.newsbeep.com/au/111000/

Cracking the sand fly code! DNA barcoding reveals 31 hidden species in India, revolutionizing insect identification. Molecular science for the win! #Genomics #MolecularTaxonomy #ScienceBreakthrough https://emmecola.github.io/genomics-daily

Postdoctoral Research Fellow
UBC School of Biomedical Engineering

The SBME at UBC (Canada) is hiring two (2) full-time Postdoctoral Research Fellows in the de Boer Lab for 16 month terms.

See the full job description on jobRxiv: https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/

#biomedicalengineering #generegulation #genomics #mac...
https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/?fsp_sid=1859

Soybean's secret weapon against salt stress: GmHAK5, GmGSTU19, GmERF98 unlock crop resilience! Breeding the future of agriculture, one gene at a time #Genomics #CropScience #PlantResearch https://emmecola.github.io/genomics-daily

**Genetic Evidence of Yersinia pestis from the First Pandemic**

"_This study provides the first genomic evidence of Y. pestis in the Eastern Mediterranean during the First Pandemic, linking archaeological findings with pathogen genomics near the origin point of the Plague of Justinian._"

Adapa, S.R.; Hendrix, K.; Upadhyay, A.; Dutta, S.; Vianello, A.; O’Corry-Crowe, G.; Monroy, J.; Ferrer, T.; Remily-Wood, E.; Ferreira, G.C.; et al. Genetic Evidence of Yersinia pestis from the First Pandemic. Genes 2025, 16, 926. https://doi.org/10.3390/genes16080926.

#OpenAccess #OA #Article #Science #Genomics #Genetics #Archaeology #Archaeodons #Anthropology #History #Pandemic #Plague #Academia @archaeodons @science

Machine learning cracks the code on fatty liver disease! Qiao et al. reveal 5 game-changing genes that could transform diagnosis & treatment. Precision medicine just got smarter! #Genomics #MedicalBreakthrough #MAFLD https://emmecola.github.io/genomics-daily

Can a single method balance sensitivity and specificity in small RNA annotation across the tree of life?

Class-agnostic annotation of small RNAs balances sensitivity and specificity in diverse organisms. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.045

CSBJ: https://www.csbj.org/

In a PacBio assembly, is it typical to get lots of terminal redundancy when sequencing plasmids or other circular elements?

I guess Canu doesn't collapse ot down?

Scientists revived an ancient gene humans lost 20M years ago—and it slashed uric acid in human cells. Could reactivating uricase cure gout and fatty liver disease? #HumanEvolution #Genomics #CRISPR https://www.anthropology.net/p/reawakening-an-ancient-gene-can-reviving

Exciting news for Uni Bonn students!
Next week, we’re welcoming Björn Pietzenuk for an inspiring career talk about #Genomics. Don’t miss the chance to hear about his journey and insights!

Botanik-Hörsaal (Nussallee 4)
6 PM c.t.
Sep 1st, Monday

https://www.izmb.uni-bonn.de/en/pbb/news#Bjoern2025
@PuckerLab

Genetic Polymorphism of Invasive Species of Knotweed (Reynoutria) Assessed by the matK and rpl32-trnL (UAG) Regions of Chloroplast DNA

https://fedia.io/m/biology@mander.xyz/t/2625747

Job Alert

CORE FACILITY MANAGER (M/F/X) Next Generation Sequencing  

Deadline: 2025-10-05 
Location: Germany, Jena, Thüringen  

→ https://www.academiceurope.com/ads/core-facility-manager-m-f-x-next-generation-sequencing/

Bacterial biogeochemical magic! Microbes oxidize sulfide using iron(III), revealing nature's hidden metabolic dance. Groundbreaking insights into elemental cycling! #Genomics #Microbiology #EcologicalFrontiers https://emmecola.github.io/genomics-daily

#Genetics
#Genomics

We're thinking of doing some small RNA sequencing. We've got the library preps down and have done it many times in the past. But those past experiments were when we could still get 1x50 or so reads on a HiSeq3000 or 4000.

Anyone have advice on what platforms will still run shorter reads? I think the NextSeq might, but I don't know. All the old machines are being sunsetted and the Novas are mostly longer, paired reads.

Genomics can help insect farmers avoid pitfalls of domestication

https://theconversation.com/genomics-can-help-insect-farmers-avoid-pitfalls-of-domestication-261357

Preparing my 'Long Read Genomics' course for a visit at the Czech University of Life Sciences Prague. Materials will be freely available on GitHub: https://github.com/bpucker/LRG
#Genomics #Bioinformatics #OpenEducation
@PuckerLab

Can CRISPR Help NK Cells Fight Cancer?

TOPLINE: Genome-wide CRISPR screens in primary human natural killer …
#NewsBeep #News #Health #AU #Australia #biologictherapy;biologics #Cancer #carcinoma #clusteredregularlyinterspacedshortpalindromicrepeats #CRISPR #CRISPR-Cas9 #genomics;genomicmedicine #malignantheadandneckneoplasm;headandneckcancer;headandneckcancer(HNC) #malignantneoplasia #malignantneoplasm #naturalkillercells;NKcells;NK-cells;naturalkiller(NK)cells
https://www.newsbeep.com/au/94300/

Ever thought about starting a plant genome sequencing project?

This open-access manual might help:

Cookbook for Plant Genome Sequences
https://www.preprints.org/manuscript/202508.1176/v1

@PuckerLab
#Genomics #Bioinformatics #LongReads #PlantSciences

Coral survival secrets revealed! Guo et al. show how reef builders fight climate change at the genomic level - DNA repair, autophagy, pure resilience! #MarineScience #ClimateAdaptation #Genomics https://emmecola.github.io/genomics-daily